Satoshi Terada博士

时间: 2017-08-31 13:00 - 14:00

地点: 北大王克桢楼1115会议室


The hippocampus is critical to both episodic memory and spatial navigation. However, many memories are not always spatial in nature, and the relationship between spatial and non-spatial memories at the neuronal information level remain still elusive. Here, we investigated the firing properties of hippocampal CA1 neurons in rats performing a cue-combination task that requires the integration of sequentially provided sound and odor cues. The majority of CA1 neurons displayed sensory cue-, combination-, or choice-specific (simply, 'event'-specific) elevated discharge activities, which were sustained throughout the event period. These event cells underwent transient theta phase precession at event onset, followed by sustained phase locking to the early theta phases. As a result of this unique single neuron behavior, the theta sequences of CA1 cell assemblies had discrete representations to encode past, present, future events. These results help to update the conceptual framework for space encoding toward a more general model of episodic event representations in the hippocampus. We hypothesize that the hippocampus may employ a common computational framework for processing sequence information of both spatial navigation and episodic memory.

邀请人: 纳家勇治研究员